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Alu-alu blister pack x 10 tablets per strip, box of 100 tablets

Store at temperatures not exceeding 30°C. Protect from sunlight and moisture.

Foods, Drugs, Devices, and Cosmetics Act prohibits dispensing without prescription

Keep out of reach of children.

For suspected averse drug reaction, report to FDA: Seek medical attention immediately at the first sign of any adverse drug reaction.


Amlodipine Besilate
5 mg and 10 mg tablet
Calcium Channel Blockers

What is Amalvex?

Amlodipine is a dihydropyridine calcium-channel blocker, and slow-channel blockers, inhibit the cellular influx of calcium which is responsible for maintenance of the plateau phase of the action potential. Thus dependent upon calcium rather than sodium influx, and these include vascular smooth muscle, myocardial cells, and cells within the sino-atrial (SA0 and atrioventricular (AV) nodes. The main actions of the calcium-channel blockers include dilatation of coronary and peripheral arteries and arterioles, with little or no effect on venous tone, a negative inotropic action, reduction of heart rate, and slowing of AV conduction.


What is the medicine used for?

For the treatment of hypertension and prophylaxis of angina.


How should the medicine be taken?

It is given by mouth as the besilate, alone or in combination with other agents, in the management of hypertension, in doses equivalent to 5 mg amlodipine daily, as a single dose.

The dose may be increased, if necessary, to the equivalent of 10 mg daily. Similar doses are given in the treatment of stable angina and Prinzmetalis angina. Small, fragile, or elderly individuals, or patients with hepatic insufficiency may be start on 2.5 mg once daily and this dose may be used in combination with other antihypertensives.

Overdosage might be expected to cause excessive peripheral vasodilatation with marked hypotension and possibly a reflex tachycardia. If massive overdosage should occur, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are essential. Should hypotension occur, cardiovascular support including elevation of the extremities and the judicious administration of fluids should be initiated. Intravenous calcium gluconate may help to reverse the effects of calcium entry blockade.


What adverse effects should I look out for?

The most common adverse effects of Amlodipine are associated with the vasodilatory action such as dizziness, flushing, headache, hypotension, and peripheral oedema. Gastro-intestinal disturbances, increased micturition frequency, lethargy, eye pain, and mental depression have also occurred. A paradoxical increase in ischaemic chest pain may occur at the start of myocardial ischaemia or transient blindness.

There have been reports of rashes, fever, and abnormalities in liver function due to hypersensitivity reactions. Gingival hyperplasia has been reported but is often reversible on drug withdrawal.

Rarely, patients, particularly those with severe obstructive coronary artery disease, have developed documented increased frequency, duration, and/or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy.



General Precautions

Since the vasodilatation included by amlodipine is gradual in onset, acute hypertension has rarely been reported after oral administration. Nonetheless, caution should be exercised when administrating amlodipine with any other peripheral vasodilator, particularly in patience with severe aortic stenosis.


Precautions for patients with Congestive Heart Failure

Amlodipine should be used with caution on patients with heart failure.


Precautions for Beta-Blocker Withdrawal

Since amlodipine is extensively metabolised by the liver and the plasma elimination, half-life is 56 hours in patients with impaired hepatic function. Caution should be exercised when administrating amlodipine to such patients.



Contraindicated in patients with known sensitivity to amlodipine.


Drug Interactions

In-vitro data in human plasma indicate that amlodipine has no effect on the protein binding of digoxin, phentoin, warfarin, and indomethacin.

It potentiates effects of thiazide diuretics and ACE inhibitors.


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