The contents of this page are provided for information purposes only. It should not be construed as a substitute for a professional medical advice and should not be relied upon in that regard. Consult your physician and other healthcare providers before taking prescription medicines found in this page.
Availability
Alu-alu blister pack x 10 tablets per strip, box of 100 tablets

Storage
Store at temperatures not exceeding 30°C. Protect from sunlight and moisture.

Caution
Foods, Drugs, Devices, and Cosmetics Act prohibits dispensing without prescription

Keep out of reach of children.

For suspected averse drug reaction, report to FDA: www.fda.gov.ph. Seek medical attention immediately at the first sign of any adverse drug reaction.

CORPLET

Clopidogrel
75 mg tablet
Antithrombotic

What is Corplet?

Clopidogrel is rapidly but incompletely absorbed following oral administration; absorption appears to be about 50%. It is a prodrug and is extensively metabolised in the liver following absorption, mainly to the inactive carboxylic acid derivative. The active metabolite appears to be a thiol derivative but has not been identified in plasma.

Clopidogrel and the carboxylic acid derivative are highly protein bound.

Clopidogrel and its metabolites are excreted about equally in urine and in feces.

 

What is the medicine used for?

Clopidogrel is an antiplatelet during used in thromboembolic disorders such as myocardial infarction, peripheral arterial disease, and stroke. It is given prophylactically as an alternative to aspirin in patients at risk of intermittent claudication and ishaemic heart disease. It is also used as an adjunct to aspirin in prevention of subacute stent occlusion intracoronary stenting.

 

How should the medicine be taken?

It is given by mouth as the Bisulfate, but doses are expressed in terms of the base; the usual dose is 75mg once daily, or as prescribed by a physician.

 

What adverse effects should I look out for?

Gastrointestinal disturbances and skin rashes are the most common reported side-effects associated with Clopidogrel therapy. Blood dyscrasias, including neutropenia and thromboetic thrombocytopenic purpura, and hemorrhagic disorders also occurred. There have been reports of hepatitis and cholestatic jaundice. Blood-lipid concentrations may increase during long-term therapy.

 

PRECAUTIONS

General Precautions

Clopidogrel should not be administered to patients with hematopoeitic disorders such as neutrapenia or thrombocytopenia, hemorrahgic diathesis or other hemorrhagic disorders associated with a prolonged bleeding time, or conditions with an increased risk of bleeding such as gastrointenstinal ulcers, acute cerebral hemorrhage or severe liver dysfunction Full blood counts should be performed before starting treatment and every 2 weeks during the first 3 months of therapy.

 

Drug Interactions

Clopidogrel should be used with caution in patients receiving other drugs, such as anticoagulants and antiplatelets, that increases the risk of bleeding. It may inhibit the metabolism of the other drugs that are metabolised in the liver. The clearance may be reduced by concomitant Cimetidine therapy. Corticosteroids may antagonize the effect of Clopidogrel on bleeding time.

 

Be part of our community!

Sign-up for our newsletter and receive exclusive updates and content.